TGF-β signaling in stromal cells acts upstream of FGF-10 to regulate epithelial stem cell growth in the adult lung

JL McQualter; RC McCarty; J Van der Velden; RJJ O'Donoghue; ML Asselin-Labat; S Bozinovski; I Bertoncello

Journal article

TGF-β signaling in stromal cells acts upstream of FGF-10 to regulate epithelial stem cell growth in the adult lung

JL McQualter, RC McCarty, J Van der Velden, RJJ O'Donoghue, ML Asselin-Labat, S Bozinovski, I Bertoncello

Stem Cell Research | ELSEVIER SCIENCE BV | Published : 2013

DOI: 10.1016/j.scr.2013.08.007

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Abstract

Tissue resident mesenchymal stromal cells (MSCs) contribute to tissue regeneration through various mechanisms, including the secretion of trophic factors that act directly on epithelial stem cells to promote epithelialization. However, MSCs in tissues constitute a heterogeneous population of stromal cells and different subtypes may have different functions. In this study we show that CD166neg and CD166pos lung stromal cells have different proliferative and differentiative potential. CD166neg lung stromal cells exhibit high proliferative potential with the capacity to differentiate along the lipofibroblastic and myofibroblastic lineages, whereas CD166pos lung stromal cells have limited prolif..

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University of Melbourne Researchers

Rosa McCarty Author

Marie-Liesse Asselin-Labat Author

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Awarded by Australian Research Council

Funding Acknowledgements

We thank Laura Fail la and Huei Jiunn Seow (Lung Health Research Centre, Australia) for their technical assistance with cell culture studies and Real-Time PCR analysis, and Yifang Hu and Gordon Smyth (The Walter and Eliza Hall Institute, Australia) for their assistance in microarray data analysis. This study was supported by grants from the Australian Stem Cell Centre (IB and JM), the National Health and Medical Research Council (NHMRC) of Australia (IB and JM Grant No. 1009374, RO Grant No. 1025239), a University of Melbourne Early Career Research Fellowship (JM), an Australian Research Council Queen Elizabeth II Fellowship (MA), and Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS.